Author:
Ma Zhigui,Guo Ke,Chen Lu,Chen Xinwei,Zou Duohong,Yang Chi
Abstract
AbstractTo investigate the role of periosteum on the treatment of buccal dehiscence defects comparing with collagen membrane in canine model. Bilateral dehiscence-type defects at the buccal side on the distal root of the lower 3rd/4th premolars were created in six beagle dogs with a total of 24 defects and assigned into three groups: Group A: blood clot in an untreated defect; Group B: deproteinized bovine bone material (DBBM) covered with an absorbable membrane; Group C: DBBM covered with the periosteum. The structural parameters for trabecular architecture and vertical bone regeneration were evaluated. Histological and histomorphometric evaluation were carried out to observe new bone formation and mineralization in the graft site. Immunohistochemical analysis was performed to identify the expression of osteopontin (OPN) and osteocalcin (OCN) at postoperative 3 months. Group C achieved greater vertical alveolar bone gain than that of group A and group B. The periosteum-covered group showed significantly greater new bone formation and accelerated mineralization. The greater immunolabeling for OPN and OCN was observed in group C than in group A. Periosteal coverage has explicit advantages over collagen membranes for the quality and quantity of new bone regeneration in dehiscence defects repairing.
Funder
Clinical Research Project of Multi-Disciplinary Team, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Publisher
Springer Science and Business Media LLC
Reference32 articles.
1. Sheikh, Z. et al. Collagen based barrier membranes for periodontal guided bone regeneration applications. Odontology 105, 1–12. https://doi.org/10.1007/s10266-016-0267-0 (2017).
2. Kasaj, A. et al. In vitro evaluation of various bioabsorbable and nonresorbable barrier membranes for guided tissue regeneration. Head Face Med. 4, 22. https://doi.org/10.1186/1746-160x-4-22 (2008).
3. Wang, H. L. & Carroll, W. J. Using absorbable collagen membranes for guided tissue regeneration, guided bone regeneration, and to treat gingival recession. Compend. Contin. Educ. Dent. (Jamesburg, N.J. : 1995) 21, 399–402 (2000) (404, 406 passim; quiz 414).
4. Rothamel, D. et al. Biocompatibility of various collagen membranes in cultures of human PDL fibroblasts and human osteoblast-like cells. Clin. Oral Implant Res. 15, 443–449. https://doi.org/10.1111/j.1600-0501.2004.01039.x (2004).
5. Chen, C. C. et al. In vitro and in vivo studies of hydrophilic electrospun PLA95/β-TCP membranes for guided tissue regeneration (GTR) applications. Nanomaterials (Basel) https://doi.org/10.3390/nano9040599 (2019).
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