Structure-guided Discovery of Dual-recognition Chemibodies-Reference-Cited by-同舟云学术

Structure-guided Discovery of Dual-recognition Chemibodies

Published:2018-05-15 Issue:1 Volume:8 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Cheng Alan C.,Doherty Elizabeth M.,Johnstone Sheree,DiMauro Erin F.,Dao Jennifer,Luthra Abhinav,Ye Jay,Tang Jie,Nixey Thomas,Min Xiaoshan,Tagari Philip,Miranda Les P.,Wang Zhulun

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-018-25848-0.pdf

Reference22 articles.

1. Wang, F. et al. Reshaping antibody diversity. Cell 153, 1379–1393 (2013).

2. Owens, J. Target validation: Determining druggability. Nature Reviews Drug Discovery 6, 187 (2007).

3. Cheng, A. C. et al. Structure-based maximal affinity model predicts small-molecule druggability. Nature Biotechnology 25, 71–75 (2007).

4. Loving, K. A., Lin, A. & Cheng, A. C. Structure-based druggability assessment of the mammalian structural proteome with inclusion of light protein flexibility. PLoS Computational Biology 10, e1003741 (2014).

5. Agarwal, P. & Bertozzi, C. R. Site-specific antibody-drug conjugates: the nexus of bioorthogonal chemistry, protein engineering, and drug development. Bioconjugate Chemistry 26, 176–192 (2015).

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