A protein scaffold, engineered SPINK2, for generation of inhibitors with high affinity and specificity against target proteases-Reference-Cited by-同舟云学术

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A protein scaffold, engineered SPINK2, for generation of inhibitors with high affinity and specificity against target proteases

Published:2019-08-07 Issue:1 Volume:9 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Nishimiya Daisuke,Kawaguchi Yoshirou,Kodama Shiho,Nasu Hatsumi,Yano Hidenori,Yamaguchi Aya,Tamura Masakazu,Hashimoto Ryuji

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-019-47615-5.pdf

Reference50 articles.

1. Owens, B. Faster, deeper, smaller-the rise of antibody-like scaffolds. Nat. Biotechnol. 35, 602–603 (2017).

2. Azhar, A. et al. Recent advances in the development of novel protein scaffolds based therapeutics. Int. J. Biol. Macromol. 102, 630–641 (2017).

3. Wurch, T., Pierré, A. & Depil, S. Novel protein scaffolds as emerging therapeutic proteins: from discovery to clinical proof-of-concept. Trends Biotechnol. 30, 575–582 (2012).

4. Stumpp, M. T., Forrer, P., Binz, H. K. & Plückthun, A. Designing repeat proteins: modular leucine-rich repeat protein libraries based on the mammalian ribonuclease inhibitor family. J. Mol. Biol. 332, 471–487 (2003).

5. Beste, G., Schmidt, F. S., Stibora, T. & Skerra, A. Small antibody-like proteins with prescribed ligand specificities derived from the lipocalin fold. Proc. Natl. Acad. Sci. USA 96, 1898–1903 (1999).

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