Author:
L’homme Laurent,Sermikli Benan Pelin,Molendi-Coste Olivier,Fleury Sébastien,Quemener Sandrine,Le Maître Mathilde,Joseph Marie-Laure,Pineau Laurent,Duhem Christian,Gross Barbara,Vallez Emmanuelle,Tailleux Anne,Staels Bart,Dombrowicz David
Abstract
AbstractRetinoic acid receptor-related orphan receptor-alpha (RORα) is a transcription factor from the nuclear receptor family expressed by immune cells and involved in the development of obesity, insulin resistance (IR) and non-alcoholic steatohepatitis (NASH). It was recently reported that mice deficient for RORα in macrophages develop more severe NASH upon high fat diet (HFD) feeding due to altered Kupffer cell function. To better understand the role of RORα in obesity and IR, we independently generated a macrophage RORα-deficient mouse line. We report that RORα deletion in macrophages does not impact on HFD-induced obesity and IR. Surprisingly, we did not confirm an effect on NASH development upon HFD feeding nor in the more severe and obesity-independent choline-deficient, L-amino acid-defined diet model. Our results therefore show that RORα deletion in macrophages does not alter the development of obesity and IR and question its role in NASH.
Funder
FP7 People: Marie-Curie Actions
Agence Nationale de la Recherche
OSEO Anvar
European Foundation for the Study of Diabetes
Fondation Francophone pour la Recherche sur le Diabète
Fondation pour la Recherche Médicale
Publisher
Springer Science and Business Media LLC
Cited by
6 articles.
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