Author:
Letsinger Ayland C.,Ward James M.,Fannin Rick D.,Mahapatra Debabrata,Bridge Matthew F.,Sills Robert C.,Gerrish Kevin E.,Yakel Jerrel L.
Abstract
AbstractIndividuals infected by SARS-CoV-2 are at risk of developing neurological-related post-acute disorders. Disputed epidemiological data indicated nicotine may reduce the severity of infection. Here we find exposure to nicotine in drinking water does not alter the moribundity of hACE2 mice. However, pre-exposure to nicotine decreased the likelihood of SARS-CoV-2 RNA expression and pathology in the brain. These results suggest mechanisms involving targets of nicotine could be leveraged to prevent the neurovirulence of SARS-CoV-2.
Funder
National Institutes of Health
NIH Intramural Research Program
Publisher
Springer Science and Business Media LLC
Cited by
2 articles.
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