Understanding the molecular basis of agonist/antagonist mechanism of human mu opioid receptor through gaussian accelerated molecular dynamics method
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Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-017-08224-2.pdf
Reference45 articles.
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3. Le Merrer, J., Becker, J. A. J., Befort, K. & Kieffer, B. L. Reward Processing by the Opioid System in the Brain. Physiological Reviews 89, 1379–1412 (2009).
4. Matthes, H. W. D. et al. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the [micro]-opioid-receptor gene. Nature 383, 819–823 (1996).
5. Bohn, L. M., Gainetdinov, R. R., Lin, F.-T., Lefkowitz, R. J. & Caron, M. G. [mu]-Opioid receptor desensitization by [beta]-arrestin-2 determines morphine tolerance but not dependence. Nature 408, 720–723 (2000).
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