Author:
Howard Ian,Howland Ian,Castle Nicholas,Al Shaikh Loua,Owen Robert
Abstract
AbstractAdverse drug events encompass a wide range of potential unintended and harmful events, from adverse drug reactions to medication errors, many of which in retrospect, are considered preventable. However, the primary challenge towards reducing their burden lies in consistently identifying and monitoring these occurrences, a challenge faced across the spectrum of healthcare, including the emergency medical services. The aim of this study was to identify and describe medication related adverse events (AEs) in the out-of-hospital setting. The medication components of a dedicated patient safety register were analysed and described for the period Jan 2017–Sept 2020. Univariate descriptive analysis was used to summarize and report on basic case and patient demographics, intervention related AEs, medication related AEs, and AE severity. Multivariable logistic regression was used to assess the odds of AE severity, by AE type. A total of 3475 patient records were assessed where 161 individual medication AEs were found in 150 (4.32%), 12 of which were categorised as harmful. Failure to provide a required medication was found to be the most common error (1.67%), followed by the administration of medications outside of prescribed practice guidelines (1.18%). There was evidence to suggest a 63% increase in crude odds of any AE severity [OR 1.63 (95% CI 1.03–2.6), p = 0.035] with the medication only AEs when compared to the intervention only AEs. Prehospital medication related adverse events remain a significant threat to patient safety in this setting and warrant greater widespread attention and future identification of strategies aimed at their reduction.
Publisher
Springer Science and Business Media LLC
Reference32 articles.
1. Kohn, L.T., Corrigan, J.M., & Donaldson, M.S. (Institute of Medicine). To err is human: building a safer health system. (Washington DC: National Academy Press, 2000)
2. Adverse Drug Events. U.S. Department of Health and Human Services; 2020 [cited 2021Jun10]. https://health.gov/our-work/health-care-quality/adverse-drug-events
3. Hohl, C. M. et al. Outcomes of emergency department patients presenting with adverse drug events. Ann. Emerg. Med. 58, 270–279 (2011).
4. Zed, P. J. et al. Incidence, severity, and preventability of medication related visits to the emergency department: a prospective study. Can. Med. Assoc. J. 178, 1563–1569 (2008).
5. McDonnell, P. J. & Jacobs, M. R. Hospital admissions resulting from preventable adverse drug reactions. Ann. Pharmacother. 36, 1331–1336 (2002).
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