Author:
Dolatyari Mahboubeh,Rostami Ali
Abstract
AbstractIn this paper, we synthesized Ag/ZnO composite colloidal nanoparticles and the surface of nanoparticles was improved by amodiaquine ligand. The synthesized nanoparticles were characterized using the XRD diffraction pattern, FT-IR Spectroscopy, TEM image, and UV–Vis spectroscopy. The antibacterial, antifungal, and antiviral effects of the synthesized colloid were examined on E.coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus hirae bacteria, and Candida Albicans and form spore aspergillus fungi, also influenza, herpes simplex, and covid 19 viruses. The results indicate more than 7 log removal of the bacteria, fungi, and viruses by synthesized colloid with a concentration of 15 μg/L (Ag)/50 µg/ml (ZnO). This removal for covid 19 virus is from 3.2 × 108 numbers to 21 viruses within 30 s. Also, irritation and toxicity tests of the synthesized colloid show harmless effects on human cells and tissues. These colloidal nanoparticles were used as mouthwash solution and their clinical tests were done on 500 people infected by the coronavirus. The results indicate that by washing their mouth and nose three times on day all patients got healthy at different times depending on the depth of the disease. Almost all people with no signs of infection and using this solution as a mouthwash didn’t infect by the virus during the study.
Publisher
Springer Science and Business Media LLC
Reference73 articles.
1. Galdiero, S. et al. Silver nanoparticles as potential antiviral agents, molecules. Pharmaceutics 16, 8894–8918 (2011).
2. Moscona, A. Medical management of influenza infection. Annu. Rev. Med. 59, 397–413 (2008).
3. Ghaebi, M., Osali, A., Valizadeh, H., Roshangar, L. & Ahmadi, M. Vaccine development and therapeutic design for 2019-nCoV/SARS-CoV-2: Challenges and chances. J. Cell Physiol. 235, 9098–9109 (2020).
4. José, A. E. & Cihlar, T. Current status and challenges of antiretroviral research and therapy. Antivir. Res. 85, 25–33 (2010).
5. Liaw, Y. F. & Chu, C. M. Hepatitis B virus infection. Lancet 373, 582–592 (2009).
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献