Author:
Salmon Eric,Bahri Mohamed Ali,Plenevaux Alain,Becker Guillaume,Seret Alain,Delhaye Emma,Degueldre Christian,Balteau Evelyne,Lemaire Christian,Luxen André,Bastin Christine
Abstract
AbstractThe purpose of this exploratory research is to provide data on synaptopathy in the behavioral variant of frontotemporal dementia (bvFTD). Twelve patients with probable bvFTD were compared to 12 control participants and 12 patients with Alzheimer’s disease (AD). Loss of synaptic projections was assessed with [18F]UCBH-PET. Total distribution volume was obtained with Logan method using carotid artery derived input function. Neuroimages were analyzed with SPM12. Verbal fluency, episodic memory and awareness of cognitive impairment were equally impaired in patients groups. Compared to controls, [18F]UCBH uptake tended to decrease in the right anterior parahippocampal gyrus of bvFTD patients. Loss of synaptic projections was observed in the right hippocampus of AD participants, but there was no significant difference in [18F]UCBH brain uptake between patients groups. Anosognosia for clinical disorder was correlated with synaptic density in the caudate nucleus and the anteromedial prefrontal cortex. This study suggests that synaptopathy in bvFTD targets the temporal social brain and self-referential processes.
Funder
Fondation Recherche Alzheimer, Belgium
Fonds De La Recherche Scientifique - FNRS
Fondation Roi Baudouin
Publisher
Springer Science and Business Media LLC
Cited by
11 articles.
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