Author:
Amalia Lisda,Saputra Gilang Nispu
Abstract
AbstractIschemic stroke is the most common stroke, caused by occlusion of cerebral vessels and leading causes of disability. Erythropoietin (EPO) has non-hematopoietic effects as a neuroprotectant after ischemic event. This study aimed to learn the serum level of EPO in acute ischemic stroke. This cross-sectional study of ischemic stroke patients with onset < 24 h and consecutive sampling was used to collect the data from medical records review, physical examinations, head CT, 24-h EPO, 24-h and seventh-day NIHSS. A total of 47 patients consisting of 59.6% women, with a median age of 53 years old (21–70). The median 24 h EPO level was 808.6 pg/mL (134.2–2988.9). The relationship between 24 h-EPO and 24-h NIHSS were not significant (r = 0.101; p = 0.250), nor to 7th day NIHSS (r = − 0.0174; p = 0.121) and to delta NIHSS (r = 0.186; p = 0.106). The relationship of blood collection time (hour) and EPO was significant (r = − 0.260; p = 0.039). There was a statistically significant difference between serum EPO levels in ischemic stroke patients with lacunar stroke compared to non-lacunar stroke (288.5 vs. 855.4 ng/mL; p = 0.021). There was a relationship between the time of collection of blood and the level of EPO and also there was difference EPO level in lacunar stroke subtype compared with non-lacunar. The relationship between EPO and NIHSS lost significance after analysis. There is a need for a future study comparing each stroke risk factor and the same blood collection time.
Funder
University of Padjadjaran
Publisher
Springer Science and Business Media LLC
Reference30 articles.
1. Akbar, M. et al. Clinical features of transient ischemic stroke patients at high recurrence risk in Indonesia. Neurol. Asia 23(2), 107–113 (2018).
2. Mestre, H., Minian, Y. C., Fainsod, D. Z. & Ibara, A. Pharmacological treatment of acute ischemic stroke. Intech Open Sci. https://doi.org/10.5572/53774 (2013).
3. Wappler, E. A., Felszeghy, K., Varshney, M., Mehra, R. D. & Nyakas Csaba, D. K. K. Brain plasticity following ischemia. Dalam: Balestrino, M. (ed). Advances in the preclinical study of ischemic stroke 89–114 (2012).
4. Fann, D. Y. W. et al. Pathogenesis of acute stroke and the role of inflammasomes. Ageing Res. Rev. 12(4), 941–966. https://doi.org/10.1016/j.arr.2013.09.004 (2013).
5. Amalia, L., Sadeli, H. A., Parwati, I., Rizal, A. & Panigoro, R. Hypoxia-inducible factor-1α in acute ischemic stroke: neuroprotection for better clinical outcome. Heliyon 6(6), e04286 (2020).