Author:
Audouin J.,Hofverberg P.,Ngono-Ravache Y.,Desorgher L.,Baldacchino G.
Abstract
AbstractUpstream of the efficiency of proton or carbon ion beams in cancer therapy, and to optimize hadrontherapy results, we analysed the chemistry of Fricke solutions in track-end of 64-MeV protons and 1.14-GeV carbon ions. An original optical setup is designed to determine the primary track-segment yields along the last millimetres of the ion track with a sub-millimetre resolution. The Fe3+-yield falls in the Bragg peak to (4.9 ± 0.4) × 10–7 mol/J and 1.9 × 10–7 mol/J, under protons and carbon ions respectively. Beyond the Bragg peak, a yield recovery is observed over 1 mm for proton beams. It is attributed to the intermediate-LET of protons in this region where their energy decreases and energy distribution becomes broader, in relation with the longitudinal straggling of the beam. Consequently to this LET decrease in the distal part of the Bragg peak, Fe3+-yield increases. For the first time, this signature is highlighted at the chemical level under proton irradiation. Nevertheless, this phenomenon is not identified for carbon ion beams since their straggling is lower. It would need a greater spatial resolution to be observed.
Funder
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
European Space Agency
Institut National Du Cancer
Publisher
Springer Science and Business Media LLC
Reference60 articles.
1. Crabtree, H. G., Cramer, W. & Gr Crabtree, B. H. The action of radium on cancer cells. II. Some factors determining the susceptibility of cancer cells to radium. Proc. R. Soc. Lond. Ser. B Contain. Pap. A Biol. Character 113, 238–250 (1933).
2. Rockwell, S., Dobrucki, I., Kim, E., Marrison, S. & Vu, V. Hypoxia and radiation therapy: Past history, ongoing research, and future promise. Curr. Mol. Med. 9, 442–458 (2009).
3. Kanemoto, A. et al. RBE and OER within the spread-out Bragg peak for proton beam therapy: In vitro study at the proton medical research center at the University of Tsukuba. J. Radiat. Res. 55, 1028–1032 (2014).
4. Brown, A. & Suit, H. The centenary of the discovery of the Bragg peak. Radiother. Oncol. 73, 265–268 (2004).
5. Newhauser, W. D. & Zhang, R. The physics of proton therapy. Phys. Med. Biol. 60, R155–R209 (2015).
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献