Lung cancer diagnosis based on weighted convolutional neural network using gene data expression

Abstract

AbstractLung cancer is thought to be a genetic disease with a variety of unknown origins. Globocan2020 report tells in 2020 new cancer cases identified was 19.3 million and nearly 10.0 million died owed to cancer. GLOBOCAN envisages that the cancer cases will raised to 28.4 million in 2040. This charge is superior to the combined rates of the former generally prevalent malignancies, like breast, colorectal, and prostate cancers. For attribute selection in previous work, the information gain model was applied. Then, for lung cancer prediction, multilayer perceptron, random subspace, and sequential minimal optimization (SMO) are used. However, the total number of parameters in a multilayer perceptron can become extremely large. This is inefficient because of the duplication in such high dimensions, and SMO can become ineffective due to its calculating method and maintaining a single threshold value for prediction. To avoid these difficulties, our research presented a novel technique including Z-score normalization, levy flight cuckoo search optimization, and a weighted convolutional neural network for predicting lung cancer. This result findings show that the proposed technique is effective in precision, recall, and accuracy for the Kent Ridge Bio-Medical Dataset Repository.