Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma-Reference-Cited by-同舟云学术

Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma

Published:2017-12 Issue:1 Volume:7 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Drew Allison E.,Moradei Oscar,Jacques Suzanne L.,Rioux Nathalie,Boriack-Sjodin Ann P.,Allain Christina,Scott Margaret Porter,Jin Lei,Raimondi Alejandra,Handler Jessica L.,Ott Heidi M.,Kruger Ryan G.,McCabe Michael T.,Sneeringer Christopher,Riera Thomas^ORCID,Shapiro Gideon,Waters Nigel J.,Mitchell Lorna H.,Duncan Kenneth W.^ORCID,Moyer Mikel P.,Copeland Robert A.,Smith Jesse,Chesworth Richard,Ribich Scott A.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-017-18446-z.pdf

Reference65 articles.

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2. Wolf, S. S. The protein arginine methyltransferase family: an update about function, new perspectives and the physiological role in humans. Cell Mol Life Sci 66, 2109–2121, https://doi.org/10.1007/s00018-009-0010-x (2009).

3. Shishkova, E. et al. Global mapping of CARM1 substrates defines enzyme specificity and substrate recognition. Nat Commun 8, 15571, https://doi.org/10.1038/ncomms15571 (2017).

4. Schurter, B. T. et al. Methylation of histone H3 by coactivator-associated arginine methyltransferase 1. Biochemistry 40, 5747–5756, doi:bi002631b [pii] (2001).

5. Wu, J., Cui, N., Wang, R., Li, J. & Wong, J. A role for CARM1-mediated histone H3 arginine methylation in protecting histone acetylation by releasing corepressors from chromatin. PLoS One 7, e34692, https://doi.org/10.1371/journal.pone.0034692PONE-D-11-24591 (2012).

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