Author:
Suzuki Sho,Tominaga Naoyuki,Aoki Tomonori,Sadashima Eiji,Miike Tadashi,Kawakami Hiroshi,Kobayashi Katsumasa,Yamauchi Atsushi,Yamada Atsuo,Omori Jun,Ikeya Takashi,Aoyama Taiki,Sato Yoshinori,Kishino Takaaki,Ishii Naoki,Sawada Tsunaki,Murata Masaki,Takao Akinari,Mizukami Kazuhiro,Kinjo Ken,Fujimori Shunji,Uotani Takahiro,Fujita Minoru,Sato Hiroki,Narasaka Toshiaki,Hayasaka Junnosuke,Funabiki Tomohiro,Kinjo Yuzuru,Mizuki Akira,Kiyotoki Shu,Mikami Tatsuya,Gushima Ryosuke,Fujii Hiroyuki,Fuyuno Yuta,Hikichi Takuto,Toya Yosuke,Narimatsu Kazuyuki,Manabe Noriaki,Nagaike Koji,Kinjo Tetsu,Sumida Yorinobu,Funakoshi Sadahiro,Kobayashi Kiyonori,Matsuhashi Tamotsu,Komaki Yuga,Kaise Mitsuru,Nagata Naoyoshi
Abstract
AbstractThe relationship between blood group and rebleeding in acute lower gastrointestinal bleeding (ALGIB) remains unclear. This study aimed to investigate the association between blood group O and clinical outcomes in patients with ALGIB. The study included 2336 patients with ALGIB whose bleeding source was identified during initial endoscopy (from the CODE BLUE-J Study). The assessed outcomes encompassed rebleeding and other clinical parameters. The rebleeding rates within 30 days in patients with blood group O and those without blood group O were 17.9% and 14.9%, respectively. Similarly, the rates within 1 year were 21.9% for patients with blood group O and 18.2% for those without blood group O. In a multivariate analysis using age, sex, vital signs at presentation, blood test findings, comorbidities, antithrombotic medication, active bleeding, and type of endoscopic treatment as covariates, patients with blood group O exhibited significantly higher risks for rebleeding within 30 days (odds ratio [OR] 1.31; 95% confidence interval [CI] 1.04–1.65; P = 0.024) and 1 year (OR 1.29; 95% CI 1.04–1.61; P = 0.020) compared to those without blood group O. However, the thrombosis and mortality rates did not differ significantly between blood group O and non-O patients. In patients with ALGIB, blood group O has been identified as an independent risk factor for both short- and long-term rebleeding.
Publisher
Springer Science and Business Media LLC