Author:
Butt Gibran F.,Hassan Ali,Wallace Graham R.,Kinoshita Shigeru,Ahmad Sajjad,Ueta Mayumi,Rauz Saaeha
Abstract
AbstractStevens–Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) are part of a disease continuum of vesiculobullous mucocutaneous reactions affecting the skin and mucous membranes including the ocular surface. Manifestations of disease range from mild dry eye to progressive conjunctival cicatrisation, limbal epithelial stem cell failure and corneal blindness. In Far Eastern and South East Asian populations where SJS/TEN is prevalent, numerous human leukocyte antigen (HLA) gene variants at the A, B and C loci have been identified as risk factors for developing SJS/TEN with severe ocular complications (SOC). By contrast, the incidence of SJS/TEN with SOC in European countries is relatively low. To date, ocular SJS/TEN risk altering alleles have not been widely investigated in European populations. In this study, we analysed the association of HLA -A, -B and -C alleles with SJS/TEN in 33 patients residing in the UK with age matched controls. The data showed statistically significant novel negative allele association with HLA-B*0702 and a trend with HLA-C*0702 in the patient group, indicating these alleles are protective. Further characterisation of protective and risk alleles in other ethnic groups is required to fully elucidate the putative role of these alleles in the susceptibility of SJS/TEN with or without severe ocular complications in patients in the UK.
Publisher
Springer Science and Business Media LLC
Reference46 articles.
1. Creamer, D. et al. U.K. guidelines for the management of Stevens–Johnson syndrome/toxic epidermal necrolysis in adults 2016. Br. J. Dermatol. 174(6), 1194–1227. https://doi.org/10.1111/bjd.14530 (2016).
2. Radford, C. F., Rauz, S., Williams, G. P., Saw, V. P. J. & Dart, J. K. G. Incidence, presenting features, and diagnosis of cicatrising conjunctivitis in the United Kingdom. Eye 26(9), 1199–1208 (2012).
3. Frey, N. et al. The epidemiology of Stevens–Johnson syndrome and toxic epidermal necrolysis in the UK. J. Invest. Dermatol. 137(6), 1240–1247 (2017).
4. Kaniwa, N. et al. HLA-B*1511 is a risk factor for carbamazepine-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in Japanese patients. Epilepsia 51(12), 2461–2465 (2010).
5. Yang, M. S. et al. Incidence of Stevens–Johnson syndrome and toxic epidermal necrolysis: a nationwide population-based study using national health insurance database in Korea. PLoS ONE 11(11), 165933 (2016).
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