Author:
Qiu Xinyue,Shen Cheng,Zhao Wenjing,Zhang Xunlei,Zhao Dakun,Wu Xuming,Yang Lei
Abstract
AbstractAlthough there have been studies correlating DYRK2 with a number of human cancers, there has been no pan-cancer analysis. Therefore, through the TCGA database, we conducted a related study on the expression of DYRK2 in cancers.The expression of DYRK2 is obviously increased in some cancers, while the opposite is true in others, and there is a clear association between its expression and the prognosis of cancer patients.The mutation of DYRK2 is also significantly correlated with patients’ prognosis in certain human tumors. In addition, phosphorylation and methylation levels of DYRK2 are different between tumor tissues and adjacent normal tissues in various tumors. In the tumour microenvironment, the expression of DYRK2 correlates with cancer-associated fibroblast infiltration, such as BLCA or HNSC. In order to fully understand the role of DYRK2 in different tumors, we conducted a pan-cancer analysis.
Funder
Medical Talent Program Foundation of Health and Family Planning Commission of Nantong
Nantong Science and Technology Foundation grant
Natural Science Foundation of Jiangsu Province
Medical Talent Program Foundation of Health and Family Planning Commission of Jiangsu Province
Publisher
Springer Science and Business Media LLC
Cited by
5 articles.
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