ELISA detection of SARS-CoV-2 antibodies in saliva

Author:

MacMullan Melanie A.,Ibrayeva Albina,Trettner Kylie,Deming Laura,Das Sudipta,Tran Frances,Moreno Jose Ricardo,Casian Joseph G.,Chellamuthu Prithivi,Kraft Jeffrey,Kozak Kenneth,Turner Fred E.,Slepnev Vladimir I.,Le Page Lydia M.

Abstract

AbstractTo facilitate containment of the COVID-19 pandemic currently active in the United States and across the world, options for easy, non-invasive antibody testing are required. Here we have adapted a commercially available, serum-based enzyme-linked immunosorbent assay (ELISA) for use with saliva samples, achieving 84.2% sensitivity and 100% specificity in a set of 149 clinical samples. This strategy will enable widespread, affordable testing for patients who experienced this disease, whilst minimizing exposure risk for healthcare workers.

Funder

Curative Inc

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference28 articles.

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