Author:
Yoon Yeonyee Elizabeth,Kim Kyoung Min,Lee Wonjae,Han Jong Soo,Chun Eun Ju,Ahn Soyeon,Choi Sang Il,Yun Bo La,Suh Jung-Won
Abstract
AbstractWe evaluated whether breast arterial calcification (BAC) is associated with the progression of coronary atherosclerosis in asymptomatic women. This retrospective observational cohort study analysed asymptomatic women from the BBC registry. In 126 consecutive women (age, 54.5 ± 7.0 years) who underwent BAC evaluation and repeated coronary computed tomography angiography (CCTA) examinations, the coronary arterial calcification score (CACS) and segment stenosis score (SSS) were evaluated to assess the progression of coronary arterial calcification (CAC) and coronary atherosclerotic plaque (CAP). CAC and CAP progression were observed in 42 (33.3%) and 26 (20.6%) women, respectively (median interscan time, 4.3 years), and were associated with the presence of BAC and a higher BAC score at baseline. Women with BAC demonstrated higher CAC and CAP progression rates and showed higher chances for CAC and CAP progression during follow-up (p < 0.001 for both). In multivariable analyses, the BAC score remained independently associated with both CAC and CAP progression rates after adjustment for clinical risk factors (β = 0.087, p = 0.029; and β = 0.020, p = 0.010, respectively) and with additional adjustment for baseline CACS (β = 0.080, p = 0.040; and β = 0.019, p = 0.012, respectively) or SSS (β = 0.079, p = 0.034; and β = 0.019, p = 0.011, respectively). Thus, BAC may be related to the progression of coronary atherosclerosis and its evaluation may facilitate decision-making.
Funder
Ministry of Science, ICT and Future Planning
Publisher
Springer Science and Business Media LLC
Reference25 articles.
1. Polonsky, T. S. & Greenland, P. Breast Arterial Calcification: Expanding the Reach of Cardiovascular Prevention. Circulation 135, 499–501 (2017).
2. Suh, J. W. & Yun, B. L. Breast Arterial Calcification: A Potential Surrogate Marker for Cardiovascular Disease. J. Cardiovasc. Imaging 26, 125–134 (2018).
3. Kemmeren, J. M. et al. Breast arterial calcifications: association with diabetes mellitus and cardiovascular mortality. Work. progress. Radiology 201, 75–78 (1996).
4. Hendriks, E. J. et al. Breast arterial calcifications: a systematic review and meta-analysis of their determinants and their association with cardiovascular events. Atherosclerosis 239, 11–20 (2015).
5. Margolies, L. et al. Digital Mammography and Screening for Coronary Artery Disease. JACC Cardiovasc. Imaging 9, 350–360 (2016).
Cited by
16 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献