Author:
Wieckiewicz Mieszko,Martynowicz Helena,Lavigne Gilles,Lobbezoo Frank,Kato Takafumi,Winocur Efraim,Wezgowiec Joanna,Danel Dariusz,Wojakowska Anna,Mazur Grzegorz,Smardz Joanna
Abstract
AbstractThis exploratory observational study aimed to evaluate whether the blood levels of serotonin and enzymes involved in serotonin synthesis are associated with sleep breathing parameters. A total of 105 patients were included in this study, who were subjected to single-night polysomnography with simultaneous audio–video recordings. Peripheral blood samples were collected to estimate the serum levels of serotonin, tryptophan hydroxylase 1 (TPH1), and aromatic l-amino acid decarboxylase (AADC). Results showed a negative correlation between blood serotonin levels, and oxygen desaturation index (ODI) (p = 0.027), central apnea (p = 0.044) and obstructive apnea (OA) (p = 0.032) scores. Blood TPH1 levels were negatively correlated with average (p = 0.003) and minimal saturation (p = 0.035) and positively correlated with apnea–hypopnea index (p = 0.010), OA (p = 0.049), and hypopnea index (p = 0.007) scores. A tendency to sleep-disordered breathing seemed to co-occur with lower blood serotonin and higher TPH1 levels.Clinical Trial Registration :www.ClinicalTrials.gov, identifier NCT04214561
Funder
Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu
Publisher
Springer Science and Business Media LLC
Cited by
2 articles.
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