Gnao1 is a molecular switch that regulates the Rho signaling pathway in differentiating neurons-Reference-Cited by-同舟云学术

Gnao1 is a molecular switch that regulates the Rho signaling pathway in differentiating neurons

Published:2024-07-24 Issue:1 Volume:14 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Taira Ryoji,Akamine Satoshi,Okuzono Sayaka,Fujii Fumihiko,Hatai Eriko,Yonemoto Kousuke,Takemoto Ryuichi,Kato Hiroki,Masuda Keiji,Kato Takahiro A.,Kira Ryutaro,Tsujimura Keita,Yamamura Kenichiro,Ozaki Norio,Ohga Shouichi,Sakai Yasunari^ORCID

Funder

Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

Ministry of Health, Labour and Welfare

Japan Epilepsy Research Foundation

Kawano Masanori Memorial Public Interest Incorporated Foundation

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41598-024-68062-x.pdf

Reference59 articles.

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2. Larasati, Y. A. et al. Restoration of the GTPase activity and cellular interactions of Galpha(o) mutants by Zn(2+) in GNAO1 encephalopathy models. Sci. Adv. 8, eabn9350. https://doi.org/10.1126/sciadv.abn9350 (2022).

3. Nakamura, K. et al. De Novo mutations in GNAO1, encoding a Galphao subunit of heterotrimeric G proteins, cause epileptic encephalopathy. Am. J. Hum. Genet. 93, 496–505. https://doi.org/10.1016/j.ajhg.2013.07.014 (2013).

4. Perez-Duenas, B. et al. The genetic landscape of complex childhood-onset hyperkinetic movement disorders. Mov. Disord. 37, 2197–2209. https://doi.org/10.1002/mds.29182 (2022).

5. Saitsu, H. et al. Phenotypic spectrum of GNAO1 variants: Epileptic encephalopathy to involuntary movements with severe developmental delay. Eur. J. Hum. Genet. 24, 129–134. https://doi.org/10.1038/ejhg.2015.92 (2016).