The Systemic Response to Topical Aldara Treatment is Mediated Through Direct TLR7 Stimulation as Imiquimod Enters the Circulation

Author:

Nerurkar LouisORCID,McColl Alison,Graham Gerard,Cavanagh Jonathan

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference28 articles.

1. Gibson, S. J. et al. Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod. Cellular Immunology 218, 74–86 (2002).

2. Patel, U., Mark, N. M., Machler, B. C. & Levine, V. J. Imiquimod 5% cream induced psoriasis: a case report, summary of the literature and mechanism. Br J Dermatol 164 (2011).

3. OND, F. C. Application Type Application Number(s) Priority or Standard Submit Date(s) Received Date(s) PDUFA Goal Date Division/Office Reviewer Name(s) Review Completion Date Established Name (Proposed) Trade Name Therapeutic Class ™™ Formulation(s) Dosing Regimen Indication(s) Intended Population(s) NDA 505 (b)(1) 201153 Standard February 8, 2010 February 24, 2010 December 8, 2010 DDDP/OND Milena Lolic, M.D. October 6, 2010 Imiquimod Zyclara cream 3.75% Not determined Graceway Cream Daily for up to 8 weeks External genital warts and perianal warts 12 years and older. 1–72 (2011).

4. van der Fits, L. et al. Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis. The Journal of Immunology 182, 5836–5845 (2009).

5. Cai, Y. et al. Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation. Immunity 35, 596–610 (2011).

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