The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells-Reference-Cited by-同舟云学术

The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells

Published:2017-07-11 Issue:1 Volume:7 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Loubiere Camille,Clavel Stephan,Gilleron Jerome,Harisseh Rania,Fauconnier Jeremy,Ben-Sahra Issam,Kaminski Lisa,Laurent Kathiane,Herkenne Stephanie,Lacas-Gervais Sandra,Ambrosetti Damien,Alcor Damien,Rocchi Stephane,Cormont Mireille,Michiels Jean-François,Mari Bernard^ORCID,Mazure Nathalie M.,Scorrano Luca^ORCID,Lacampagne Alain,Gharib Abdallah,Tanti Jean-François^ORCID,Bost Frederic

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-017-05052-2.pdf

Reference40 articles.

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3. Zakikhani, M., Dowling, R., Fantus, I. G., Sonenberg, N. & Pollak, M. Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res. 66, 10269–10273 (2006).

4. El-Mir, M. Y. et al. Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem. 275, 223–228 (2000).

5. Bridges, H. R., Jones, A. J., Pollak, M. N. & Hirst, J. Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria. Biochem J 462, 475–487 (2014).

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