Author:
Svendsen Kristoffer,Guénot Diego,Svensson Jonas Björklund,Petersson Kristoffer,Persson Anders,Lundh Olle
Abstract
AbstractAn electron beam of very high energy (50–250 MeV) can potentially produce a more favourable radiotherapy dose distribution compared to a state-of-the-art photon based radiotherapy technique. To produce an electron beam of sufficiently high energy to allow for a long penetration depth (several cm), very large accelerating structures are needed when using conventional radio-frequency technology, which may not be possible due to economical or spatial constraints. In this paper, we show transport and focusing of laser wakefield accelerated electron beams with a maximum energy of 160 MeV using electromagnetic quadrupole magnets in a point-to-point imaging configuration, yielding a spatial uncertainty of less than 0.1 mm, a total charge variation below $$1 \%$$
1
%
and a focal spot of $$2.3 \times 2.6\;{\text {mm}}^2$$
2.3
×
2.6
mm
2
. The electron beam was focused to control the depth dose distribution and to improve the dose conformality inside a phantom of cast acrylic slabs and radiochromic film. The phantom was irradiated from 36 different angles to obtain a dose distribution mimicking a stereotactic radiotherapy treatment, with a peak fractional dose of 2.72 Gy and a total maximum dose of 65 Gy. This was achieved with realistic constraints, including 23 cm of propagation through air before any dose deposition in the phantom.
Funder
Knut and Alice Wallenberg Foundation
Swedish Research Council
Crafoord Foundation
Laserlab-Europe
ARIES
Lund University
Publisher
Springer Science and Business Media LLC
Cited by
15 articles.
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