Author:
Choi Seung-Min,Jeong Jae-Chan,Kim Jinsun,Lim Eul-Gyoon,Kim Chang-beom,Park Sang-Jin,Song Dae-Yong,Krause Hans-Joachim,Hong Hyobong,Kweon In So
Abstract
AbstractThe magnetic particle imaging (MPI) is a technology that can image the concentrations of the superparamagnetic iron oxide nanoparticles (SPIONs) which can be used in biomedical diagnostics and therapeutics as non-radioactive tracers. We proposed a point-of-care testing MPI system (PoCT-MPI) that can be used for preclinical use for imaging small rodents (mice) injected with SPIONs not only in laboratories, but also at emergency sites far from laboratories. In particular, we applied a frequency mixing magnetic detection method to the PoCT-MPI, and proposed a hybrid field free line generator to reduce the power consumption, size and weight of the system. The PoCT-MPI is $$20 \times 33 \times 45\,{\hbox{cm}}^3$$20×33×45cm3 in size and weighs less than 100 kg. It can image a three-dimensional distribution of SPIONs injected into a biosample with less than 120 Wh of power consumption. Its detection limit is $$0.13\,\upmu {\hbox{L}}$$0.13μL, 10 mg/mL, $$1.3\,\upmu {\hbox{g}}$$1.3μg (Fe).
Funder
IITP grant funded by MSIP of the South Korean government
Publisher
Springer Science and Business Media LLC
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