Author:
Iwakura Katsuomi,Onishi Toshinari,Okamura Atsunori,Koyama Yasushi,Tanaka Nobuaki,Okada Masato,Fujii Kenshi,Seo Masahiro,Yamada Takahisa,Yano Masamichi,Hayashi Takaharu,Yasumura Yoshio,Nakagawa Yusuke,Tamaki Shunsuke,Nakagawa Akito,Sotomi Yohei,Hikoso Shungo,Nakatani Daisaku,Sakata Yasushi, ,Watanabe Tetsuya,Higuchi Yoshiharu,Masuda Masaharu,Asai Mitsutoshi,Mano Toshiaki,Fuji Hisakazu,Masuda Daisaku,Shutta Ryu,Yamashita Shizuya,Sairyo Masami,Abe Haruhiko,Ueda Yasunori,Matsumura Yasushi,Nagai Kunihiko,Nishino Masami,Tanouchi Jun,Arita Yoh,Ogasawara Nobuyuki,Ishizu Takamaru,Ichikawa Minoru,Takano Yuzuru,Rin Eisai,Shinoda Yukinori,Tachibana Koichi,Hoshida Shiro,Izumi Masahiro,Yamamoto Hiroyoshi,Kato Hiroyasu,Nakatani Kazuhiro,Yasuga Yuji,Nishio Mayu,Hirooka Keiji,Yoshimura Takahiro,Kashiwase Kazunori,Hasegawa Shinji,Tani Akihiro,Okumoto Yasushi,Makino Yasunaka,Kijima Yoshiyuki,Kitao Takashi,Fujita Masashi,Harada Koichiro,Kumada Masahiro,Nakagawa Osamu,Araki Ryo,Yamada Takayuki,Matsuoka Yuki,Sato Taiki,Sunaga Akihiro,Oeun Bolrathanak,Kida Hirota,Dohi Tomoharu,Akazawa Yasuhiro,Nakamoto Kei,Okada Katsuki,Sera Fusako,Kioka Hidetaka,Ohtani Tomohito,Takeda Toshihiro,Mizuno Hiroya
Abstract
AbstractThe coexistence of heart failure is frequent and associated with higher mortality in patients with type 2 diabetes (T2DM), and its management is a critical issue. The WATCH-DM risk score is a tool to predict heart failure in patients with type 2 diabetes mellitus (T2DM). We investigated whether it could estimate outcomes in T2DM patients with heart failure with preserved ejection fraction (HFpEF). The WATCH-DM risk score was calculated in 418 patients with T2DM hospitalized for HFpEF (male 49.5%, age 80 ± 9 years, HbA1c 6.8 ± 1.0%), and they were divided into the “average or lower” (≤ 10 points), “high” (11–13 points) and “very high” (≥ 14 points) risk groups. We followed patients to observe all-cause death for 386 days (median). We compared the area under the curve (AUC) of the WATCH-DM score for predicting 1-year mortality with that of the Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) score and of the Barcelona Bio-Heart Failure Risk (BCN Bio-HF). Among the study patients, 108 patients (25.8%) had average or lower risk scores, 147 patients (35.2%) had high risk scores, and 163 patients (39.0%) had very high risk scores. The Cox proportional hazard model selected the WATCH-DM score as an independent predictor of all-cause death (HR per unit 1.10, 95% CI 1.03 to 1.19), and the “average or lower” risk group had lower mortality than the other groups (p = 0.047 by log-rank test). The AUC of the WATCH-DM for 1-year mortality was 0.64 (95% CI 0.45 to 0.74), which was not different from that of the MAGGIC score (0.72, 95% CI 0.63 to 0.80, p = 0.08) or that of BCN Bio-HF (0.70, 0.61 to 0.80, p = 0.25). The WATCH-DM risk score can estimate prognosis in T2DM patients with HFpEF and can identify patients at higher risk of mortality.
Publisher
Springer Science and Business Media LLC
Cited by
1 articles.
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1. Methods to predict heart failure in diabetes patients;Expert Review of Endocrinology & Metabolism;2024-04-15