Heterozygous mutations in valosin-containing protein (VCP) and resistance to VCP inhibitors
Author:
Funder
U.S. Department of Defense
American Cancer Society
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-019-47085-9.pdf
Reference34 articles.
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2. Kim, N. C. et al. VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. Neuron 78, 65–80, https://doi.org/10.1016/j.neuron.2013.02.029 (2013).
3. Beskow, A. et al. A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation. Journal of molecular biology 394, 732–746, https://doi.org/10.1016/j.jmb.2009.09.050 (2009).
4. Franz, A. et al. CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication. Molecular cell 44, 85–96, https://doi.org/10.1016/j.molcel.2011.08.028 (2011).
5. Bastola, P., Oien, D. B., Cooley, M. & Chien, J. Emerging Cancer Therapeutic Targets in Protein Homeostasis. 20, 94, https://doi.org/10.1208/s12248-018-0254-1 (2018).
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