Author:
Yamazaki Tomoe,Ushikoshi-Nakayama Ryoko,Shakya Supriya,Omagari Daisuke,Matsumoto Naoyuki,Nukuzuma Chiyoko,Komatsu Tomoko,Lee Masaichi Chang-il,Inoue Hiroko,Saito Ichiro
Abstract
AbstractPercutaneously absorbed carbon dioxide enhances blood flow. The mechanism by which it does so is unclear, but we hypothesized that it involves bicarbonate ions. BALB/c mice were bathed in neutral bicarbonate ionized water (NBIW) and showed increased blood bicarbonate levels and blood flow via phosphorylation of peripheral vascular endothelial nitric oxide synthase (eNOS) and production of nitric oxide (NO). Phosphorylation of eNOS and NO production were also increased in human umbilical vein endothelial cells cultured in medium containing NBIW, and NBIW showed reactive oxygen species scavenging activity. In a double-blind, randomized study in men and women aged 30 to 59 years with subjective cold intolerance, bathing in NBIW elevated body temperature faster than bathing in a control solution and improved chills and sleep quality. Taken together, our results show that percutaneously absorbed carbon dioxide changes to bicarbonate ions, which act directly on endothelial cells to increase NO production by phosphorylation of eNOS and thus improve blood flow.
Funder
MEXT-Supported Program for the Strategic Research Foundation at Private Universities
Publisher
Springer Science and Business Media LLC
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