Anti-PCSK9 antibodies inhibit pro-atherogenic mechanisms in APOE*3Leiden.CETP mice
Author:
Funder
Amgen
Sanofi
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-019-47242-0.pdf
Reference54 articles.
1. Abifadel, M. et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nature genetics 34, 154–156, https://doi.org/10.1038/ng1161 (2003).
2. Abifadel, M. et al. Mutations and polymorphisms in the proprotein convertase subtilisin kexin 9 (PCSK9) gene in cholesterol metabolism and disease. Human mutation 30, 520–529, https://doi.org/10.1002/humu.20882 (2009).
3. Cohen, J. et al. Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nature genetics 37, 161–165, https://doi.org/10.1038/ng1509 (2005).
4. Lopez, D. PCSK9: an enigmatic protease. Biochimica et biophysica acta 1781, 184–191, https://doi.org/10.1016/j.bbalip.2008.01.003 (2008).
5. Seidah, N. G., Awan, Z., Chretien, M. & Mbikay, M. PCSK9: a key modulator of cardiovascular health. Circulation research 114, 1022–1036, https://doi.org/10.1161/circresaha.114.301621 (2014).
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