Author:
Hu Wei,Li Ping,Zeng Nianju,Tan Sheng
Abstract
AbstractIschemic stroke is highly concerning because it often leads to severe long-term neurological disability. Among clinical trials, ischemic stroke and inflammatory bowel disease interactions have been increasingly reported in recent years. Therefore, using bioinformatics approaches to explore novel protein interactions between them is of interest. We performed this exploratory analysis by using bioinformatics tools such as string to analyze gene data downloaded from NHGRI-GWAS data related to ischemic stroke and inflammatory bowel disease. We constructed a prospective protein interaction network for ischemic stroke and inflammatory bowel disease, identifying cytokine and interleukin-related signaling pathways, Spliceosome, Ubiquitin–Proteasome System (UPS), Thrombus, and Anticoagulation pathways as the crucial biological mechanisms of the network. Furthermore, we also used data-independent acquisition mass spectrometry (DIA-MS) to detect differential protein expression in eight samples, which also suggested that immune system, signal transduction, and hemostasis-related pathways are key signaling pathways. These findings may provide a basis for understanding the interaction between these two states and exploring possible molecular and therapeutic studies in the future.
Funder
Natural Science Foundation of Hunan Province, China
Publisher
Springer Science and Business Media LLC
Reference86 articles.
1. Ovbiagele, B. et al. Forecasting the future of stroke in the United States: A policy statement from the American Heart Association and American Stroke Association. Stroke 44(8), 2361–2375 (2013).
2. Tsao, C. W. et al. Heart disease and stroke statistics-2022 update: A report from the American heart association. Circulation 145(8), e153–e639 (2022).
3. Centers for Disease C, Prevention. Prevalence and most common causes of disability among adults--United States, 2005. MMWR Morb. Mortal Wkly Rep. 58(16), 421–426 (2009).
4. Ogawa, H., Yamamoto, K., Kamisako, T. & Meguro, T. Phytosterol additives increase blood pressure and promote stroke onset in salt-loaded stroke-prone spontaneously hypertensive rats. Clin. Exp. Pharmacol. Physiol. 30(12), 919–924 (2003).
5. Collaborators GBDLRoS, Feigin, V.L., Nguyen, G., Cercy, K., Johnson, C. O., Alam, T., Parmar, P.G., Abajobir, A.A., Abate, K.H., Abd-Allah, F., et al. Global, regional, and country-specific lifetime risks of stroke, 1990 and 2016. N. Engl. J. Med. 379(25), 2429–2437 (2018).
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