Formaldehyde exposure induces regulatory T cell-mediated immunosuppression via calcineurin-NFAT signalling pathway

Author:

Park Jeongsik,Yang Hyo-Seon,Song Mi-Kyung,Kim Dong Im,Lee Kyuhong

Abstract

AbstractIn this study, we investigated the effects of Formaldehyde (FA) exposure on splenic immune responses wherein helper T cells become activated and differentiate into effector T and regulatory T cells. BALB/c mice were exposed to two FA concentrations (1.38 mg/m3 and 5.36 mg/m3) for 4 h/day and 5 days/week for 2 weeks. FA-induced immune responses were examined by the production of cytokines, expression of mRNAs, and distributions of helper T cells and regulatory T cells. Moreover, expression of calcineurin and NFATs, regulatory T cell-related signalling proteins, were evaluated. FA exposure suppressed Th2-, Th1-, and Th17-related splenic cytokines in a dose-dependent manner. mRNA expression of splenic cytokines was also decreased by FA exposure, which correlated with decreased cytokine expression. In parallel, FA exposure promoted T cell differentiation into regulatory T cells in a dose-dependent manner supported by the expression of calcineurin and NFAT1. Taken together, our results indicated that FA exposure increases the number of regulatory T cells via calcineurin-NFAT signalling, thereby leading to effector T cell activity suppression with decreased T cell-related cytokine secretion and mRNA expression. These findings provide insight into the mechanisms underlying the adverse effects of FA and accordingly have general implications for human health, particularly in occupational settings.

Funder

Korea Institute of Toxicology

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference73 articles.

1. Kilburn, K. H. Indoor air effects after building renovation and in manufactured homes. Am. J. Med. Sci. 320, 249–254 (2000).

2. Ezratty, V. et al. Effect of formaldehyde on asthmatic response to inhaled allergen challenge. Environ. Health Perspect. 115, 210–214 (2006).

3. Carlson, R. M., Smith, M. C. & Nedorost, S. T. Diagnosis and treatment of dermatitis due to formaldehyde resins in clothing. Dermat. Contact Atop. Occup. Drug 15, 169–175 (2004).

4. EPA, U. S. IRIS Toxicological Review of Formaldehyde (Inhalation) (External Review Draft 2010). (2010).

5. Agner, T., Flyvholm, M.-A. & Menné, T. Formaldehyde allergy: a follow-up study. Am. J. Contact Dermat. 10, 12–17 (1999).

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3