Author:
Xue Qun,Li Xiaoping,Gu Yanzheng,Wang Xiaozhu,Wang Mingyuan,Tian Jingluan,Duan Xiaoyu,Gao Hanqing,Ji Xiaopei,Yan Xiaoming,Dong Wanli,Fang Qi,Zhang Xueguang
Abstract
Abstract
Neuromyelitis optica spectrum disorder (NMOSD) likely results from humoral immune abnormalities. The role that helper T cells play in the pathogenesis of this disease is not fully understood. To ascertain the clinical significance of two important costimulatory molecules required for T-cell activation in the peripheral blood of patients with NMOSD, we examined the expression levels of a membrane- and soluble-type inducible costimulatory molecule (ICOS), its ligand (ICOSL), programmed death-1 (PD-1), and its ligand (PD-L1) in the peripheral blood of 30 patients with NMOSD and compared these levels with those in patients with longitudinally extensive transverse myelitis (LETM), those with optic neuritis (ON), and healthy controls (HCs). Our results showed that the ICOS/ICOSL and PD-1/PD-L1 pathways may play important roles in the early stages of NMOSD pathogenesis. ICOS and PD-1 are potential therapeutic targets and valuable biomarkers for the differential diagnosis of early-stage NMOSD.
Publisher
Springer Science and Business Media LLC
Reference41 articles.
1. Lennon, V. A. et al. A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet 364, 2106–2112 (2004).
2. Neuroimmune Committee of Chinese Society for Immunology, Neuroimmunology Group of Neurology Branch of Chinese Medical Association & Neuroimmunology Committee of Neurology Branch of Chinese Medical Doctor Association. Chinese guidelines for the diagnosis and management of neuromyelitis optica spectrum disorders. Chin. J. Neuroimmunol. Neurol. 23, 155–166 (2016).
3. Pohl, M. et al. T cell-activation in neuromyelitis optica lesions plays a role in their formation. Acta Neuropathol. Commun. 1, 85 (2013).
4. Li, Y. J. et al. Association of circulating follicular helper T cells with disease course of NMO spectrum disorders. J. Neuroimmunol. 278, 239–246 (2015).
5. Dong, H., Zhu, G., Tamada, K. & Chen, L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat. Med. 5, 1365–1369 (1999).
Cited by
11 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献