Author:
O’Sullivan Dylan E.,Metcalfe Amy,Hillier Troy W. R.,King Will D.,Lee Sangmin,Pader Joy,Brenner Darren R.
Abstract
AbstractThe objective of this study was to identify distinct clusters of individuals that exhibit unique patterns of modifiable lifestyle-related behaviours and to determine how these patterns are associated with the risk of developing colorectal cancer (CRC). The study consisted of 26,460 participants and 267 CRC cases from Alberta’s Tomorrow Project. Exploratory latent class analysis of risk behaviours (obesity, physical inactivity, meat consumption, smoking, alcohol consumption, and fruit and vegetable consumption) and Cox proportional hazard models were utilized. Seven unique behavioural groups were identified, where the risk of CRC was 2.34 to 2.87 times greater for high risk groups compared to the low risk group. Sex-specific models identified higher risk groups among men (Hazard Ratios [HRs]: 3.15 to 3.89) than among women (HRs: 1.99 to 2.19). Targeting groups defined by clustering of behaviours could potentially lead to more effective prevention of CRC on a population level.
Publisher
Springer Science and Business Media LLC
Reference28 articles.
1. Brenner, D. R. et al. Projected burden of cancer in Canada in 2020. Can. Med. Assoc. J. 192, E199–E205 (2020)
2. Haggar, F. A. & Boushey, R. P. Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors. Clin. Colon. Rectal. Surg. 22, 191–197 (2009).
3. Edwards, B. K. et al. Annual report to the nation on the status of cancer, 1975–2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates. Cancer 116, 544–573 (2010).
4. Poirier, A. E. et al. The current and future burden of cancer attributable to modifiable risk factors in Canada: Summary of results. Prev. Med. 122, 140–147 (2019).
5. World Cancer Research Fund/American Institute for Cancer Research. Diet, Nutrition, Physical Activity and Cancer: A Global Perspective 3rd edn. (American Institute for Cancer Research, Washington, DC, 2018).
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献