Author:
Liu Leilei,Lei Juan,Zhang Linyuan,Ma Nana,Xu Zixuan,Peng Lian,Nie Chan,Zhong Jianqin,Zhang Xiao,Hong Feng
Abstract
AbstractComprehensive research on rural–urban disparities in the association of hyperuricaemia (HUA) with cardiovascular disease (CVD) in China, especially among minority groups, is limited. We explored the HUA-CVD relationship between rural and urban areas within ethnic Chinese groups. We included Dong, Miao, and Bouyei adults in Southwest China from the China Multi-Ethnic Cohort Study. Multivariable logistic regression models were used to assess the relationship between HUA and CVD in both residences. We performed stratified analyses by sex and age. The study population included 16,618 people (37.48% Dong, 30.00% Miao, and 32.52% Bouyei) without a reduced estimated glomerular filtration rate. We identified 476 (188 Dong, 119 Miao, and 169 Bouyei) and 175 (62 Dong, 77 Miao, and 36 Bouyei) CVD cases in rural and urban areas. Compared to urban residents, an at least 49% increased CVD risk (adjusted OR 1.49, 95%CI 1.06–2.08 for the Dong ethnic group; 1.55, 1.07–2.25 for the Bouyei ethnic group) and a 1.65-fold elevated coronary heart disease risk (1.65, 1.03–2.64) related to HUA was present in rural residents. Moreover, HUA was positively associated with increased risk of CVD and coronary heart disease in rural women (2.05, 1.26–3.31; 2.11, 1.19–3.75) and rural older adults (1.83, 1.22–2.75; 2.32, 1.39–3.87) among the Bouyei ethnic group, respectively. We found rural elderly individuals with HUA among the Dong ethnic group had a 52% elevated risk of CVD (1.52, 1.05–2.21); furthermore, an at least 79% increased risk of stroke related to HUA was observed in women (2.24, 1.09–4.62) and elderly people (1.79, 1.02–3.13) in rural areas among the Dong ethnic group. But a positive association was not found among the Miao ethnic group. Screening early-onset HUA patients may be helpful for the control and prevention of CVD in rural residents, especially for women and older adults living in a rural community, among the Dong and Bouyei ethnic groups in China.
Funder
the National Key R&D Program of China
the Science and Technology Plan Project of Guizhou Province, China
Publisher
Springer Science and Business Media LLC
Reference33 articles.
1. Zhao, D. Epidemiological features of cardiovascular disease in Asia. JACC Asia. 1, 1–13 (2021).
2. Su, J. T., Zhang, Y. M., Wang, P., Du, J. & Wei, Z. H. Comparative analysis of comprehensive health status among 31 provinces in China and 134 countries (regions) in 2015. Chin. J. Prev. Med. 54, 165–168 (2020).
3. Tu, W. et al. Asymptomatic hyperuricemia and incident stroke in elderly Chinese patients without comorbidities. Eur. J. Clin. Nutr. 73, 1392–1402 (2019).
4. Lai, X. et al. Dose-response relationship between serum uric acid levels and risk of incident coronary heart disease in the Dongfeng-Tongji Cohort. Int. J. Cardiol. 224, 299–304 (2016).
5. Yang, Y. et al. Relationship between hyperuricemia and risk of coronary heart disease in a middle-aged and elderly Chinese population. J. Int. Med. Res. 45, 254–260 (2017).
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献