Author:
Nicolini Paola,Mari Daniela,Abbate Carlo,Inglese Silvia,Bertagnoli Laura,Tomasini Emanuele,Rossi Paolo D.,Lombardi Federico
Abstract
AbstractMild cognitive impairment (MCI) is a heterogeneous syndrome with two main clinical subtypes, amnestic (aMCI) and non-amnestic (naMCI). The analysis of heart rate variability (HRV) is a tool to assess autonomic function. Cognitive and autonomic processes are linked via the central autonomic network. Autonomic dysfunction entails several adverse outcomes. However, very few studies have investigated autonomic function in MCI and none have considered MCI subtypes or the relationship of HRV indices with different cognitive domains and structural brain damage. We assessed autonomic function during an active orthostatic challenge in 253 oupatients aged ≥ 65, [n = 82 aMCI, n = 93 naMCI, n = 78 cognitively normal (CN), neuropsychologically tested] with power spectral analysis of HRV. We used visual rating scales to grade cerebrovascular burden and hippocampal/insular atrophy (HA/IA) on neuroimaging. Only aMCI showed a blunted response to orthostasis. Postural changes in normalised low frequency (LF) power and in the LF to high frequency ratio correlated with a memory test (positively) and HA/IA (negatively) in aMCI, and with attention/executive function tests (negatively) and cerebrovascular burden (positively) in naMCI. These results substantiate the view that the ANS is differentially impaired in aMCI and naMCI, consistently with the neuroanatomic substrate of Alzheimer's and small-vessel subcortical ischaemic disease.
Publisher
Springer Science and Business Media LLC
Reference143 articles.
1. Petersen, R. C. et al. Mild cognitive impairment: A concept in evolution. J. Intern. Med. 275, 214–228 (2014).
2. United Nations, Department of Economic and Social Affairs, Population Division. World Population Ageing 2019—highlights. (United Nations, 2019). Available at: https://www.un.org/en/development/desa/population/publications/pdf/ageing/WorldPopulationAgeing2019-Highlights.pdf
3. Bermejo-Pareja, F. et al. Prognostic significance of mild cognitive impairment subtypes for dementia and mortality: data from the NEDICES cohort. J. Alzheimers Dis. 50, 719–731 (2016).
4. Hughes, T. F., Snitz, B. E. & Ganguli, M. Should mild cognitive impairment be subtyped?. Curr. Opin. Psychiatry. 24, 237–242 (2011).
5. Knopman, D. S. et al. Spectrum of cognition short of dementia: Framingham Heart Study and Mayo Clinic Study of Aging. Neurology. 85, 1712–1721 (2015).
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