Author:
Tumanova Kseniia,Serra Stefano,Majumdar Anamitra,Lad Jigar,Quereshy Fayez,Khorasani Mohammadali,Vitkin Alex
Abstract
AbstractThe peri-tumoural stroma has been explored as a useful source of prognostic information in colorectal cancer. Using Mueller matrix (MM) polarized light microscopy for quantification of unstained histology slides, the current study assesses the prognostic potential of polarimetric characteristics of peri-tumoural collagenous stroma architecture in 38 human stage III colorectal cancer (CRC) patient samples. Specifically, Mueller matrix transformation and polar decomposition parameters were tested for association with 5-year patient local recurrence outcomes. The results show that some of these polarimetric parameters were significantly different (p value < 0.05) for the recurrence versus the no-recurrence patient cohorts (Mann–Whitney U test). MM parameters may thus be prognostically valuable towards improving clinical management/treatment stratification in CRC patients.
Funder
New Frontiers in Research Fund
Canadian Institutes of Health Research
Natural Sciences and Engineering Research Council of Canada
Publisher
Springer Science and Business Media LLC
Cited by
1 articles.
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