Pharmaceutically modified subtilisins withstand acidic conditions and effectively degrade gluten in vivo
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-019-43837-9.pdf
Reference45 articles.
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2. Helmerhorst, E. J., Zamakhchari, M., Schuppan, D. & Oppenheim, F. G. Discovery of a novel and rich source of gluten-degrading microbial enzymes in the oral cavity. PLoS One 5, e13264, https://doi.org/10.1371/journal.pone.0013264 (2010).
3. Gass, J. & Khosla, C. Prolyl endopeptidases. Cell Mol Life Sci 64, 345–355, https://doi.org/10.1007/s00018-006-6317-y (2007).
4. Dieterich, W. et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 3, 797–801 (1997).
5. Caputo, I., Lepretti, M., Martucciello, S. & Esposito, C. Enzymatic strategies to detoxify gluten: implications for celiac disease. Enzyme Res 2010, 174354, https://doi.org/10.4061/2010/174354 (2010).
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