Author:
Chung Jae-Wook,Park Dong Jin,Chun So Young,Choi Seock Hwan,Lee Jun Nyung,Kim Bum Soo,Kim Hyun Tae,Kim Tae-Hwan,Yoo Eun Sang,Byun Seok-Soo,Hwang Eu Chang,Kang Seok Ho,Hong Sung-Hoo,Chung Jinsoo,Kwak Cheol,Kim Yong- June,Ha Yun-Sok,Kwon Tae Gyun
Abstract
AbstractThis multi-institutional study sought to clarify the association between the preoperative serum albumin/globulin ratio (AGR) and the prognosis of renal cell carcinoma (RCC) in a large cohort. This study encompassed eight institutions and 2,970 non-metastatic RCC patients who underwent a radical or partial nephrectomy from the Korean RCC (KORCC) database. A low AGR (1,143 patients; 38.5%) was defined as a preoperative AGR of less than 1.47 and a high AGR (1,827 patients; 61.5%) was defined as that 1.47 or greater. In the low AGR group, older age, female gender, the incidence of symptom presentation when diagnosed, diabetes, and hypertension was higher than in the high AGR group. Patients with low AGRs showed more progressive tumor stages with higher Fuhrman nuclear grades (all P-values < 0.05). Patients in the low AGR group had a significantly lower overall survival rate (OS) and recurrence-free survival rate (RFS) in the Kaplan–Meier curves (all P-values < 0.05). AGR was an independent prognostic factor for predicting the OS and RFS in the multivariate analysis (all P-values < 0.05). The preoperative AGR is approachable and economical to use clinically for estimating the prognosis of RCC patients treated with surgery.
Funder
National Research Foundation of Korea
Publisher
Springer Science and Business Media LLC
Cited by
15 articles.
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