Spatio-temporal dynamics of Plasmodium falciparum transmission within a spatial unit on the Colombian Pacific Coast

Author:

Knudson Angélica,González-Casabianca Felipe,Feged-Rivadeneira AlejandroORCID,Pedreros Maria Fernanda,Aponte Samanda,Olaya Adriana,Castillo Carlos F.,Mancilla Elvira,Piamba-Dorado Anderson,Sanchez-Pedraza Ricardo,Salazar-Terreros Myriam Janeth,Lucchi Naomi,Udhayakumar Venkatachalam,Jacob Chris,Pance AlenaORCID,Carrasquilla ManuelaORCID,Apráez Giovanni,Angel Jairo Andrés,Rayner Julian C.ORCID,Corredor VladimirORCID

Abstract

AbstractAs malaria control programmes concentrate their efforts towards malaria elimination a better understanding of malaria transmission patterns at fine spatial resolution units becomes necessary. Defining spatial units that consider transmission heterogeneity, human movement and migration will help to set up achievable malaria elimination milestones and guide the creation of efficient operational administrative control units. Using a combination of genetic and epidemiological data we defined a malaria transmission unit as the area contributing 95% of malaria cases diagnosed at the catchment facility located in the town of Guapi in the South Pacific Coast of Colombia. We provide data showing that P. falciparum malaria transmission is heterogeneous in time and space and analysed, using topological data analysis, the spatial connectivity, at the micro epidemiological level, between parasite populations circulating within the unit. To illustrate the necessity to evaluate the efficacy of malaria control measures within the transmission unit in order to increase the efficiency of the malaria control effort, we provide information on the size of the asymptomatic reservoir, the nature of parasite genotypes associated with drug resistance as well as the frequency of the Pfhrp2/3 deletion associated with false negatives when using Rapid Diagnostic Tests.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference79 articles.

1. World Health Organization. World Malaria Report 2019 (Geneva: World Health Organization, 2019).

2. World Health Organization. Global Technical Strategy for Malaria 2016-2030 (Genova: World Health Organization, 2015).

3. PAHO. Informe de la situación de la malaria en las Américas, 2014. Washington: Pan American Health Organization (2014).

4. Instituto Nacional de Salud. Boletin Epidemiológico Semanal, número 52 (Colombia: Instituto Nacional de Salud, 2016).

5. Instituto Nacional de Salud. Boletin Epidemiológico Semanal, número 52 (Colombia: Instituto Nacional de Salud, 2017).

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