Author:
Abbas Waseem,Howard Jeremy T.,Paz Henry A.,Hales Kristin E.,Wells James E.,Kuehn Larry A.,Erickson Galen E.,Spangler Matthew L.,Fernando Samodha C.
Abstract
AbstractIn light of recent host-microbial association studies, a consensus is evolving that species composition of the gastrointestinal microbiota is a polygenic trait governed by interactions between host genetic factors and the environment. Here, we investigated the effect of host genetic factors in shaping the bacterial species composition in the rumen by performing a genome-wide association study. Using a common set of 61,974 single-nucleotide polymorphisms found in cattle genomes (n = 586) and corresponding rumen bacterial community composition, we identified operational taxonomic units (OTUs), Families and Phyla with high heritability. The top associations (1-Mb windows) were located on 7 chromosomes. These regions were associated with the rumen microbiota in multiple ways; some (chromosome 19; position 3.0–4.0 Mb) are associated with closely related taxa (Prevotellaceae, Paraprevotellaceae, and RF16), some (chromosome 27; position 3.0–4.0 Mb) are associated with distantly related taxa (Prevotellaceae, Fibrobacteraceae, RF16, RFP12, S24-7, Lentisphaerae, and Tenericutes) and others (chromosome 23; position 0.0–1.0) associated with both related and unrelated taxa. The annotated genes associated with identified genomic regions suggest the associations observed are directed toward selective absorption of volatile fatty acids from the rumen to increase energy availability to the host. This study demonstrates that host genetics affects rumen bacterial community composition.
Funder
U.S. Department of Agriculture
Multi-state Research project
Publisher
Springer Science and Business Media LLC
Reference59 articles.
1. Anderson, C. L., Schneider, C. J., Erickson, G. E., MacDonald, J. C. & Fernando, S. C. Rumen bacterial communities can be acclimated faster to high concentrate diets than currently implemented feedlot programs. J. Appl. Microbiol. 120, 588–599. https://doi.org/10.1111/jam.13039 (2016).
2. Church, D. C. The Ruminant Animal Digestive Physiology and Nutrition (Waveland Press Inc, Long Grove, 1993).
3. Hobson, P. N. The Rumen Microbial Ecosystem (Elsevier Applied Science, London, 1988).
4. Hungate, R. E. The Rumen and Its Microbes (Academic Press Inc, London, 1966).
5. Li, F. et al. Host genetics influence the rumen microbiota and heritable rumen microbial features associate with feed efficiency in cattle. Microbiome 7, 92. https://doi.org/10.1186/s40168-019-0699-1 (2019).
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