Hybrid approach to sieve out natural compounds against dual targets in Alzheimer’s Disease
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-019-40271-9.pdf
Reference68 articles.
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3. Ghosh, A. K. et al. Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase). J. Am. Chem. Soc. 122, 3522–3523 (2000).
4. Hong, L. et al. Structure of the Protease Domain of Memapsin 2 (beta -Secretase) Complexed with Inhibitor. Science 290, 150–153 (2000).
5. Asai, M. et al. The novel β-secretase inhibitor KMI-429 reduces amyloid β peptide production in amyloid precursor protein transgenic and wild-type mice. J. Neurochem. 96, 533–540 (2006).
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