Author:
Orsi Gergely,Hayden Zsofia,Cseh Tamas,Berki Timea,Illes Zsolt
Abstract
AbstractOsteopontin (OPN) is a proinflammatory marker produced by systemic immune and central nervous system (CNS) resident cells. We examined, if the level of OPN in the cerebrospinal fluid (CSF) and blood is associated with late-time regional brain volumes and white matter (WM) lesion load in MS. Concentrations of OPN in blood and CSF were related to MRI findings 10.1 ± 2.0 years later in 46 patients with MS. OPN concentration was measured by ELISA, while regional brain volumes and lesion load was assessed by magnetic resonance imaging (MRI) using 3D MPRAGE sequence and automated MR volumetry. OPN measured in the CSF was associated with several regional brain volumes and WM lesion load measured 10.1 ± 2.0 years later. CSF OPN concentration correlated with long-term enlargement of lateral- and inferior lateral ventricles and the elevation of gross CSF volume, in conjunction with the reduction of several cortical/subcortical gray matter and WM volumes. Serum OPN showed no long-term association with regional brain volumes. OPN measured from the CSF but not from the serum was associated with lower regional brain volumes measured a decade later, indicating the primary role of inflammation within the CNS in developing long-term brain related alterations.
Funder
“The role of neuro-inflammation in neurodegeneration: from molecules to clinics”, the Institutional Excellence Program for the Higher Education II within the framework of the 5th thematic program
Thematic Excellence Programme by the National Research, Development and Innovation Fund of Hungary
Hungarian Brain Research Program
University of Pécs Medical School Research Fund
Odense University Hospital and Rigshospital joint grant
Publisher
Springer Science and Business Media LLC
Cited by
7 articles.
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