Sustained virological response to hepatitis C therapy does not decrease the incidence of systemic lupus erythematosus or rheumatoid arthritis
-
Published:2020-03-25
Issue:1
Volume:10
Page:
-
ISSN:2045-2322
-
Container-title:Scientific Reports
-
language:en
-
Short-container-title:Sci Rep
Author:
Hsu Wei-FanORCID, Chen Chi-Yi, Tseng Kuo-Chih, Lai Hsueh-Chou, Kuo Hsing-Tao, Hung Chao-Hung, Tung Shui-Yi, Wang Jing-Houng, Chen Jyh-Jou, Lee Pei-Lun, Chien Rong-Nan, Lin Chun-YenORCID, Yang Chi-Chieh, Lo Gin-Ho, Tai Chi-Ming, Lin Chih-Wen, Kao Jia-HorngORCID, Liu Chun-JenORCID, Liu Chen-HuaORCID, Yan Sheng-Lei, Bair Ming-Jong, Su Wei-Wen, Chu Cheng-Hsin, Chen Chih-Jen, Lo Ching-Chu, Cheng Pin-NanORCID, Chiu Yen-Cheng, Wang Chia-Chi, Cheng Jin-Shiung, Tsai Wei-Lun, Lin Han-Chieh, Huang Yi-HsiangORCID, Tsai Pei-Chien, Huang Jee-Fu, Dai Chia-Yen, Chuang Wan-Long, Yu Ming-LungORCID, Peng Cheng-YuanORCID
Abstract
AbstractIn patients with chronic hepatitis C (CHC), the effects of baseline characteristics, virological profiles, and therapeutic outcome to pegylated interferon plus ribavirin (PR) therapy on autoimmune diseases are unknown. Taiwanese Chronic Hepatitis C Cohort is a nationwide hepatitis C virus registry cohort comprising 23 hospitals of Taiwan. A total of 12,770 CHC patients receiving PR therapy for at least 4 weeks between January 2003 and December 2015 were enrolled and their data were linked to the Taiwan National Health Insurance Research Database for studying the development of 10 autoimmune diseases. The mean follow-up duration was 5.3 ± 2.9 years with a total of 67,930 person-years, and the annual incidence of systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA) was 0.03%. Other autoimmune diseases were not assessable due to few events. Body mass index ≥24 kg/m2 was an independent predictor of the low incidence of SLE or RA (hazard ratio 0.40, 95% confidence interval 0.17–0.93, p = 0.034). A sustained virological response (SVR) to PR therapy was not associated with the low incidence of SLE or RA in any subgroup analysis. CHC patients achieving SVR to PR therapy did not exhibit an impact on the incidence of SLE or RA compared with non-SVR patients.
Funder
China Medical University Hospital Kaohsiung Medical University Ministry of Health and Welfare
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Reference29 articles.
1. El-Serag, H. B., Hampel, H., Yeh, C. & Rabeneck, L. Extrahepatic manifestations of hepatitis C among United States male veterans. Hepatology 36, 1439–1445, https://doi.org/10.1053/jhep.2002.37191 (2002). 2. Cacoub, P. et al. Extrahepatic manifestations of chronic hepatitis C. MULTIVIRC Group. Multidepartment Virus C. Arthritis Rheum 42, 2204–2212, https://doi.org/10.1002/1529-0131(199910)42:10##2204::AID-ANR24$$3.0.CO;2-D (1999). 3. Jacobson, I. M., Cacoub, P., Dal Maso, L., Harrison, S. A. & Younossi, Z. M. Manifestations of chronic hepatitis C virus infection beyond the liver. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association 8, 1017–1029, https://doi.org/10.1016/j.cgh.2010.08.026 (2010). 4. Hsu, Y. C. et al. Association between antiviral treatment and extrahepatic outcomes in patients with hepatitis C virus infection. Gut 64, 495–503, https://doi.org/10.1136/gutjnl-2014-308163 (2015). 5. Panel, A.-I. H. G. Hepatitis C Guidance 2018 Update: AASLD-IDSA Recommendations for Testing, Managing, and Treating Hepatitis C Virus Infection. Clin Infect Dis 67, 1477–1492, https://doi.org/10.1093/cid/ciy585 (2018).
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|