Author:
Alegre-Zurano Laia,Caceres-Rodriguez Alba,Berbegal-Sáez Paula,Lassalle Olivier,Manzoni Olivier,Valverde Olga
Abstract
AbstractA single dose of cocaine abolishes endocannabinoid-mediated long-term depression (eCB-LTD) in the nucleus accumbens (NAc) within 24 h of administration. However, it is uncertain whether this altered neuroplasticity entails a behavioral deficit. As previously reported, after a single dose of cocaine (20 mg/kg), mice displayed impaired eCB-LTD in the NAc. Such cocaine-induced neuroplastic impairment was accompanied by an altered preference for saccharin and social interactions and a reduction in mRNA levels of the anandamide-catabolizing enzyme NAPE-PLD. The pharmacological increase of anandamide through the fatty acid amide hydrolase (FAAH) inhibitor URB597 (1 mg/kg) reversed the cocaine-induced loss of eCB-LTD in the NAc and restored normal social interaction in cocaine-exposed mice, but it did not affect saccharin preference. Overall, this research underlines the neuroplastic and behavioral alterations occurring after the initial use of cocaine and suggests a potential role for anandamide.
Funder
Ministerio de Educación y Formación Profesional
Institut National de la Santé et de la Recherche Médicale
Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya
Agencia Estatal de Investigación
Ministerio de Sanidad, Servicios Sociales e Igualdad
Departament d'Empresa i Coneixement, Generalitat de Catalunya
Publisher
Springer Science and Business Media LLC