Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models-Reference-Cited by-同舟云学术

Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models

Published:2018-10-18 Issue:1 Volume:8 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Brooks Harold B.,Meier Timothy I.,Geeganage Sandaruwan,Fales Kevin R.,Thrasher Kenneth J.,Konicek Susan A.,Spencer Charles D.,Thibodeaux Stefan^ORCID,Foreman Robert T.,Hui Yu-Hua,Roth Kenneth D.,Qian Yue-Wei,Wang Tao,Luo Shuang,Torrado Alicia,Si Chong,Toth James L.,Mc Cowan Jefferson R.,Frimpong Kwame,Lee Matthew R.,Dally Robert D.,Shepherd Timothy A.,Durham Timothy B.,Wang Yong,Wu Zhipei,Iversen Philip W.,Njoroge F. George

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-018-33453-4.pdf

Reference38 articles.

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3. Racanelli, A. C., Rothbart, S. B., Heyer, C. L. & Moran, R. G. Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition. Cancer research 69, 5467–5474, https://doi.org/10.1158/0008-5472.CAN-08-4979 (2009).

4. Cronstein, B. N. & Kamen, B. A. 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICA-riboside) as a targeting agent for therapy of patients with acute lymphoblastic leukemia: are we there and are there pitfalls? Journal of Pediatric Hematology/Oncology 29, 805–807 (2007).

5. Swinnen, J. V. et al. Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype. Cancer research 65, 2441–2448, https://doi.org/10.1158/0008-5472.CAN-04-3025 (2005).

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