Author:
Pakdaman Hossein,Harandi Ali Amini,Gharagozli Koroush,Alaeddini Farshid,Esfandani Akram,Mirbehbahani Seyed Hamidreza,Doroudi Taher,Kolivand Pirhossein,Bahrami Parviz,Kazemi Hadi
Abstract
AbstractEpilepsy has garnered increased public health focus because patients who suffer from epilepsy experience pronounced and persistent health and socioeconomic disparities despite treatment and care advances. The epidemiology of epilepsy is diverse in different countries and regions. This nationwide population-based cross-sectional study was conducted to determine the life time prevalence and health related factors of epilepsy for the first time in Iran through a two-phase door-to-door survey method. In phase I, a screening for epilepsy was performed on 68,035 people. Then in phase II, after the neurological evaluation of participants and reviewing medical records, 1130 subjects with epilepsy was confirmed. The life time prevalence of epilepsy was achieved to be 16.6 per 1000 people (95% CI 15.4–17.8) with the average age onset 19.1 ± 21.1 (active prevalence 9.5 per 1000 people). Focal seizure (59.3%), generalized epilepsy (38%) and unknown types of epilepsy (2.7%) were detected among participants. The overall life time prevalence of febrile convulsion was 4.1 per 1000 people. The frequency of attacks per year and per month were 3.0 ± 1.6 and 0.5 ± 0.1, respectively. Age-specific life time prevalence was highest among the age group of 15–19 years old [32.7 per 1000 persons (95% CI 29.1–36.8)] and it was higher in male (53.8%) than female (46.2%) participants. Our results showed that the life time prevalence of epilepsy in Iran is higher than worldwide average.
Funder
Shahid Beheshti University of Medical Sciences
Publisher
Springer Science and Business Media LLC
Reference46 articles.
1. Fiest, K. M. et al. Prevalence and incidence of epilepsy: A systematic review and meta-analysis of international studies. Neurology 88(3), 296–303. https://doi.org/10.1212/WNL.0000000000003509 (2017).
2. Radhakrishnan, K. Challenges in the management of epilepsy in resource-poor countries. Nat. Rev. Neurol. 5(6), 323–330. https://doi.org/10.1038/nrneurol.2009.53 (2009).
3. Ngugi, A. K. et al. Prevalence of active convulsive epilepsy in sub-Saharan Africa and associated risk factors: cross-sectional and case-control studies. Lancet Neurol. 12(3), 253–263. https://doi.org/10.1016/S1474-4422(13)70003-6 (2013).
4. Ngugi, A. K., Bottomley, C., Kleinschmidt, I., Sander, J. W. & Newton, C. R. Estimation of the burden of active and life-time epilepsy: A meta-analytic approach. Epilepsia 51(5), 883–890. https://doi.org/10.1111/j.1528-1167.2009.02481.x (2010).
5. Sayehmiri, K., Tavan, H., Sayehmiri, F., Mohammadi, I. & Carson , K. V. Prevalence of epilepsy in Iran: A meta-analysis and systematic review. Iran J. Child Neurol. 8(4), 9–17 (2014).