Author:
Chen Hao,Matsumoto Hiromi,Horita Nobuyuki,Hara Yu,Kobayashi Nobuaki,Kaneko Takeshi
Abstract
AbstractRisk factors associated with mortality in invasive pneumococcal disease remain unclear. The present work is a meta-analysis of studies that enrolled only patients with invasive pneumococcal disease and reported on mortality. Potentially eligible reports were identified from PubMed, CHAHL, and Web of Science, comprising 26 reports in total. Overall mortality for invasive pneumococcal disease was reported as 20.8% (95% confidence interval (CI) 17.5–24%). Factors associated with mortality were age (odds ratio (OR) 3.04, 95% CI 2.5–3.68), nursing home (OR 1.62, 95% CI 1.13–2.32), nosocomial infection (OR 2.10, 95% CI 1.52–2.89), septic shock (OR 13.35, 95% CI 4.54–39.31), underlying chronic diseases (OR 2.34, 95% CI 1.78–3.09), solid organ tumor (OR 5.34, 95% CI 2.07–13.74), immunosuppressed status (OR 1.67, 95% CI 1.31–2.14), and alcohol abuse (OR 3.14, 95% CI 2.13–4.64). Mortality rates with invasive pneumococcal disease remained high, and these findings may help clinicians provide appropriate initial treatment for this disease.
Publisher
Springer Science and Business Media LLC
Reference41 articles.
1. Drijkoningen, J. J. & Rohde, G. G. Pneumococcal infection in adults: burden of disease. Clin. Microbiol. Infect. 20(Suppl 5), 45–51 (2014).
2. Centers for Disease Control and Prevention. ABCs Report: Streptococcus pneumoniae, 2018. https://www.cdc.gov/abcs/reports-findings/survreports/spneu18.html (2018).
3. Chalmers, J. D., Campling, J., Dicker, A., Woodhead, M. & Madhava, H. A systematic review of the burden of vaccine preventable pneumococcal disease in UK adults. BMC Pulm Med. 16, 77 (2016).
4. Bonnave, C. et al. Adult vaccination for pneumococcal disease: a comparison of the national guidelines in Europe. Europ. J. Clin. Microbiol. Infect. Dis Clin. Microbiol. Infect. 38, 785–791 (2019).
5. Marrie, T. J., Tyrrell, G. J., Majumdar, S. R. & Eurich, D. T. Effect of age on the manifestations and outcomes of invasive pneumococcal disease in adults. Am. J. Med. 131, 100e1-100e7 (2018).