Nebulized hypertonic saline triggers nervous system-mediated active liquid secretion in cystic fibrosis swine trachea
Author:
Funder
Gouvernement du Canada | Canadian Institutes of Health Research
Cystic Fibrosis Canada
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-018-36695-4.pdf
Reference44 articles.
1. Donaldson, S. H. et al. Mucus clearance and lung function in cystic fibrosis with hypertonic saline. N. Engl. J. Med. 354, 241–250 (2006).
2. Elkins, M. R. & Bye, P. T. Inhaled hypertonic saline as a therapy for cystic fibrosis. Curr. Opin. Pulm. Med. 12, 445–452 (2006).
3. Tildy, B. E. & Rogers, D. F. Therapeutic options for hydrating airway mucus in cystic fibrosis. Pharmacology 95, 117–132 (2015).
4. Reeves, E. P. et al. Inhaled hypertonic saline for cystic fibrosis: Reviewing the potential evidence for modulation of neutrophil signalling and function. World J. Crit. Care Med. 4, 179–191 (2015).
5. Ellemunter, H., Eder, J., Fuchs, S., Gappa, M. & Steinkamp, G. Long-term improvement of lung clearance index in patients with mild cystic fibrosis lung disease: Does hypertonic saline play a role? J. Cyst. Fibros. 15, 123–126 (2016).
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