Magnetically guided non-invasive CRISPR-Cas9/gRNA delivery across blood-brain barrier to eradicate latent HIV-1 infection
Author:
Funder
U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-019-40222-4.pdf
Reference41 articles.
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2. Nair, M., Jayant, R. D., Kaushik, A. & Sagar, V. Getting into the brain: Potential of nanotechnology in the management of NeuroAIDS. Advanced drug delivery reviews 103, 203–217 (2016).
3. Kaushik, A., Jayant, R. D. & Nair, M. Nanomedicine for neuroHIV/AIDS management. Nanomedicine, https://doi.org/10.2217/nnm-2018-0005 (2018).
4. Kaminski, R. et al. Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing. Scientific reports 6 (2016).
5. Zhang, Y. et al. CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs. Scientific reports 5 (2015).
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