Author:
Suchodolski Jakub,Derkacz Daria,Bernat Przemysław,Krasowska Anna
Abstract
AbstractThe effect of capric acid, secreted by the probiotic yeasts Saccharomyces boulardii, was evaluated on the activities of fluconazole (FLC) and amphotericin B (AMB) against pathogenic Candida albicans fungus. The findings indicated that capric acid may be a promising additive for use in combination with FLC. A FLC-capric acid combination led to reduced efflux activity of multidrug resistance (MDR) transporter Cdr1p by causing it to relocalize from the plasma membrane (PM) to the interior of the cell. The above effect occurred due to inhibitory effect of FLC-capric acid combination of ergosterol biosynthesis. However, capric acid alone stimulated ergosterol production in C. albicans, which in turn generated cross resistance towards AMB and inhibited its action (PM permeabilization and cytoplasm leakage) against C. albicans cells. This concluded that AMB should not be administered among dietary supplements containing capric acid or S. boulardii cells.
Publisher
Springer Science and Business Media LLC
Reference42 articles.
1. Puel, A. et al. Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science (80-) 332, 65–68 (2011).
2. Whaley, S. G. et al. Azole antifungal resistance in Candida albicans and emerging non-albicans Candida Species. Front. Microbiol. 7, 2173 (2017).
3. Dadar, M. et al. Candida albicans - Biology, molecular characterization, pathogenicity, and advances in diagnosis and control – An update. Microb. Pathog. 117, 128–138 (2018).
4. Alizadeh, F., Khodavandi, A. & Zalakian, S. Quantitation of ergosterol content and gene expression profile of ERG11 gene in fluconazole-resistant Candida albicans. Curr. Med. Mycol. 3, 13–19 (2017).
5. Beardsley, J., Halliday, C. L., Chen, S. C. A. & Sorrell, T. C. Responding to the emergence of antifungal drug resistance: perspectives from the bench and the bedside. Future Microbiol. 13, 1175–1191 (2018).
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