Calcitonin native prefibrillar oligomers but not monomers induce membrane damage that triggers NMDA-mediated Ca2+-influx, LTP impairment and neurotoxicity
Author:
Funder
Ministero della Salute
Ministero dell'Istruzione, dell'Università e della Ricerca
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-019-41462-0.pdf
Reference69 articles.
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2. Glabe, C. G. Common mechanisms of amyloid oligomer pathogenesis in degenerative disease. Neurobiol. Aging. 27(4), 570–575, https://doi.org/10.1016/j.neurobiolaging.2005.04.017 (2006).
3. Diociaiuti, M. et al. Native metastable prefibrillar oligomers are the most neurotoxic species among amyloid aggregates. Biochim. Biophys. Acta 1842, 1622–1629, https://doi.org/10.1016/j.bbadis.2014.06.006 (2014).
4. Kamgar-Parsi, K. et al. Structural Biology of Calcitonin: From Aqueous Therapeutic Properties to Amyloid Aggregation. Isr. J. Chem. 57, 634–650, https://doi.org/10.1002/ijch.201600096 (2017).
5. Benilova, I., Karran, E. & De Strooper, B. The toxic Aβ oligomer and Alzheimer’s disease: an emperor in need of clothes. Nat. Neurosci. 15, 349–357, https://doi.org/10.1038/nn.3028 (2012).
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